USMH is housed in the renovated Baldwin Complex in downtown Hagerstown. The original building was built in 1790 as the Globe Tavern. It later became the Baldwin House Hotel and eventually was home to Leiter’s Department Store, which was purchased by Routzahn’s Department Store. The complex had been vacated since the 1980s and was in disrepair when the State purchased it and began renovation in 2001. The original structure was renovated and maintains the Italianate style. This section of the facility provides office space in what were once hotel rooms. A contemporary addition allows space for state-of-the-art classrooms and computer labs.

The completed renovation with the addition is 77,000 square feet. It boasts 44 offices, 22 classrooms, four interactive video network (IVN) classrooms, six computer labs, two nursing labs and a library/media center.

USMH opened in January 2005 with three universities offering seven undergraduate and five graduate programs. Currently, there are five universities offering 13 undergraduate and eight graduate programs.